Klonopin is a drug from the benzodiazepine group, which has a hypnotic, sedative, anticonvulsant effect. In official medicine, it is used to treat epilepsy, anxiety-phobic disorders, restless legs syndrome, and other pathologies. If therapeutic doses and duration of treatment are exceeded, it causes strong chemical dependence.
| Tablet Strength | pills | Pricev | Per pill Price |
| 2mg | 300 | $755.01 | 2.52 |
Klonopin: mechanism of action
The drug inhibits the transmission of nerve impulses and suppresses excitation processes. Being an agonist of GABA receptors, it inhibits the production of neurotransmitters responsible for psychomotor activity. Due to this, a calming, anti-anxiety, and muscle relaxant effect of Klonopin is achieved.
The drug is quickly and completely absorbed in the intestine. The peak concentration of Clonazepam is reached 1-4 hours after oral administration. Most of it (85%) is in a state bound to plasma proteins. The main route of elimination of Klonopin and its metabolites is excretion by the kidneys, so kidney disease can affect the concentration of this drug in the blood.
Klonopin undergoes significant biochemical transformations in the body, and only about 2% of the original drug is excreted in the urine unchanged. Cytochrome C-450 in the liver plays a certain role in its metabolism, so liver disease can affect the concentration of this drug in the blood.
The drug is most often used to relieve muscle hypertonicity, eliminate and prevent seizures, stabilize the psychoemotional background, relieve symptoms of social phobia and other behavioral disorders. In addition to therapeutic purposes, Klonopin is used for premedication in preparation for general anesthesia.
Contraindications to the use of Xanax
- Physiological effects
- relaxation of skeletal muscles;
- reduction of mental stress, alignment of the general psychoemotional background;
- elimination of emotional lability, irritability, anxiety, fear;
- acceleration of falling asleep;
- prevention of convulsions, epileptic seizures.
Pathological effects
If therapeutic doses are exceeded, the following may occur:
- headaches, dizziness;
- severe drowsiness, lethargy, decreased performance;
- decreased clarity of consciousness, inhibition of thinking, weakened concentration;
- speech impairment;
- memory impairment up to its partial or complete loss;
- nausea, dry mouth, vomiting;
- suppression of appetite, abdominal pain;
- rapid pulse, low blood pressure.
With prolonged use of Klonopin in high doses, cognitive functions and intellectual abilities inevitably degrade, the state of the psyche is disturbed, the emotional sphere and speech are impoverished.
Sometimes, Klonopin causes side effects opposite to therapeutic ones:
- nervous excitement, increased speech and motor activity;
- anxiety, fear, irritability;
- panic attacks, paranoid and other psychotic states;
- insomnia;
- convulsions, epileptic seizures.
Recommended dosage
The 0.5 mg divisible tablets allow for lower daily doses at the beginning of treatment, if needed. The dosage and duration of therapy should be personalized by the physician. Treatment should start at a low dose, which is gradually increased until the desired therapeutic effect is achieved.
Overdose
An overdose of Klonopin occurs when its dose is exceeded, taken simultaneously with other psychoactive substances, alcohol, as well as in case of exhaustion of the body, in old age, in the presence of concomitant somatic or mental disorders.
How can poisoning with the drug manifest itself?
- confusion up to its complete loss and development of coma;
- epileptic seizures, oscillations of the eyeballs;
- disorientation in space and time;
- drop in blood pressure, tachycardia, shallow breathing;
- vomiting, diarrhea, nausea.
